Opposite the hotel is the Gothic Church of the Holy Spirit. Its tower dominates the Heidelberg townscape. The imposing 15th-century building is made from sandstone blocks from the Neckar Valley and sits on the Marktplatz (Market Square) together with the Rathaus (Town Hall).

The Hotel zum Ritter St. Georg and the Church of the Holy Spirit are the only large buildings in the town that were spared from destruction during the War of the Palatine Succession.

Built between 1398 and 1515 it served as the burial place of the Prince Electors of the Electoral Palatinate and a symbolic house of God. Today only the tomb of King Ruprecht I can be found here. The Church of the Holy Spirit was once also home to the most important European library, the Bibliotheca Palatina, which is now located in Heidelberg University Library.